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Updated: Jun 5, 2026
Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
[Neuropathologic investigation of area tempestas sclerosis in epileptic sensitive rats]
Xin-Lu Du1, Jie Zhao, Wan-Qin Zhang
1Department of Physiology, Dalian Medical University, Dalian 116027, China.
Aim And Methods:
The relation between AT sclerosis (loss of neurons and proliferation of astrocytes) and long-lasting epileptic susceptibility was investigated by thionine staining, GFAP immunohistochemistry and observing the behavior of rats, after scorpion venom (SV) or normal saline (NS) administrated for three week.
Results:
Compared with NS+ NS group, both the loss of neurons and proliferation of astrocytes were very marked in KA+ NS group (epileptic susceptible rats) (P < 0.05), but those changes were not visible in KA+ NS group (epileptic nonsusceptible rats).
Conclusions:
It suggested that AT sclerosis may be one of important reasons of the long-lasting epileptic susceptibility.
