Related Experiment Video
Updated: Jun 5, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Risk factors for diabetic nephropathy: intrinsic or extrinsic renal?
E Moţa1, M N Panduru, Simona G Popa
1University of Medicine and Pharmacy, Craiova, Romania. profmota@umfcv.ro
Abstract:
Diabetic nephropathy (DN) is the result of numerous risk factors, such as hyperglycaemia, several genetic polymorphisms, offering susceptibility or individual resistance to DN. There are numerous, well-studied risk factors for DN, the majority being renal extrinsic, but there have been identified and studied renal intrinsic factors (the number of glomeruli, the volume of glomeruli) which can be structural determinants of the risk for the development of DN and may be precocious markers of DN. The clarification of the role of genetic factors in the pathogeny of DN may contribute to the evaluation of DN risk, allowing the selection of patients eligible to new precocious therapies (primary prevention) and the prevention of ESRD (secondary prevention).
Related Concept Videos
Diabetic Nephropathy
Chronic Kidney Disease I: Introduction
Diabetic Retinopathy
Type II Diabetes I: Introduction
External Anatomy of the Kidney
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Acute Kidney Injury II: Pathophysiology