Related Experiment Video
Updated: Jun 5, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Four hundred meters walking test in the evaluation of heart failure patients
D Zdrenghea1, Maria Beudean, Dana Pop
1Department of Cardiology, Rehabilitation Hospital "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca. dzdrenghea@yahoo.com
Insights
The new 400-meter walking test (400mWT) offers a valuable alternative for assessing heart failure patients' exercise capacity. It provides similar results to the 6-minute walking test (6MWT) but better evaluates peripheral involvement.
Area of Science:
- Cardiology
- Exercise Physiology
- Rehabilitation
Background:
- Maximal exercise stress testing is optimal for heart failure (HF) prognosis but impractical for large patient numbers.
- Submaximal tests like the 6-minute walking test (6MWT) assess daily effort capacity but have limitations.
- The 6MWT may not fully motivate patients or equally involve peripheral muscles crucial for HF management.
Purpose of the Study:
- To introduce and compare a novel fixed-distance test, the 400-meter walking test (400mWT), against the 6MWT and maximal exercise testing.
- To evaluate the utility of 400mWT for assessing submaximal exercise capacity in heart failure patients.
Main Methods:
- Twenty patients with dilated cardiomyopathy (DCM) post-congestive syndrome relief were studied.
- Each patient underwent maximal symptom-limited exercise stress testing, the 6MWT, and the 400mWT on consecutive days.
- The 400mWT involved walking a 40-meter corridor at self-selected speed, with time to complete 400m recorded.
Main Results:
- Mean peak VO2 during maximal testing was 15.2 mL O2/kg/min (4.32 METs).
- Mean 6MWT distance was 350m; mean 400mWT time was 300 seconds.
- Excellent correlation (r = -0.60) was found between 6MWT distance and 400mWT time, suggesting similar assessment of exercise capacity.
Conclusions:
- The 400-meter walking test (400mWT) is a practical tool for evaluating submaximal exercise capacity in chronic heart failure (CHF) patients.
- 400mWT demonstrates comparable utility to the 6MWT for assessing exercise capacity.
- 400mWT may offer a superior evaluation of peripheral involvement in heart failure patients compared to the 6MWT.
Unlabelled:
The best evaluation of the severity and prognosis of heart failure patients is obtained by the maximal exercise stress testing, but for the very large number of HF patients and for evaluation of their daily effort capacity submaximal stress testing, mainly 6 minutes walking test are used. The limit of 6mWT is that during it the patients are not motivated to walk and also, the periphery, so important for heart failure patients, is not equally involved.
Objective:
To compare a new fixed walking test-400m walking test with 6MWT and maximal exercise testing.
Methods:
There were investigated 20 patients with dilated cardiomyopathy (DCM). The patients were included in the study after the relief of the congestive syndrome. Each patient was submitted in three consecutive days to a maximal symptom-limited exercise stress test on cycloergometer, a six minutes walking test, a 400 meters walking test. The last one consisted of walking on a corridor 40 meters long, at a speed chosen by the patient himself. The results were expressed in seconds representing the necessary time to cover the established 400 meters of distance.
Results:
During cycloergometer exercise stress test the calculated mean peak VO2 was 15.2 +/- 1.4 mlO2/kg/min (4.32 METs). The mean distance walked during 6MWT was 350 +/- 34m and the mean time needed to walk 400m (400mWT) was 300 +/- 27 seconds. The correlation between peak VO2 and distance walked during 6MWT was -0.40, a similar but negative value (r = -0.42) being registered between peak VO2 and time registered during 400mWT. Only weak correlation was registered between LVEF and all the three tests. In turn the correlation between distance registered during 6MWT and time registered during 400mWT was excellent: r = -0.60.
Conclusion:
400mWT is a useful tool for the evaluation of submaximal effort capacity of CHF patients. Its value to evaluate exercise capacity is similar with that of the 6 MWT, but 400mWT can assure a better evaluation of peripheral involvement.
Related Concept Videos
Heart Failure IV: Classification and Diagnostic Evaluation
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Heart Failure VII: Nursing Interventions
Heart Failure V: Medical Management
Heart Failure VI: Adjunct Therapies
Pathophysiology of Heart Failure
