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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
Alejandro F Barrero1, M Mar Herrador, José F Quílez del Moral
1Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avda Fuente Nueva, s/n, 18071 Granada, Spain. afbarre@ugr.es
Abstract:
Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described.
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