Related Experiment Video
Updated: Jun 5, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Image characters of optical coherence tomography in laser-induced maculopathy]
Hui Xiao1, Xing Liu, Jingjing Huang
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Purpose:
To observe the changes of ocular fundus and to describe the image features of optical coherence tomography (OCT) in patients with laser-induced maculopathy.
Methods:
Four patients (4 eyes) with decreased visual acuity due to laser injury were recruited into the study between April 2002 to December 2009. All patients underwent routine check-up for eyes.
Results:
The four cases presented with different clinical characteristics from each another. In the first case, OCT showed lamella macular hole, with partially remained outer sensory retina. The signals of inner segments/outer segments (IS/OS) band and RPE band were disrupted. The choroidal band was distorted with increased reflection. Perimacular epiretinal membrane and vitreous hemorrhage were also observed. The second case had a full-thickness macular hole with retina edema surrounding the hole. The third case presented local serous sensory retinal detachment in macula. The fourth case presented hyper-reflection of the inner retina in macula which indicated hemorrhage.
Conclusion:
There are various patterns of laser-induced maculopathy. OCT is a useful noninvasive diagnostic tool to delineate the layer, extent and configuration of the damage on retina.
