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[Association between HBV genotype and chronic/severe liver disease with HBV infection in Chinese patients]
Ai-Min Zhang1, Hui-Fen Wang, Hai-Bin Wang
1Liver Failure Treatment and Research Center, 302nd Hospital of PLA, Beijing 100039, China.
Insights
Hepatitis B virus (HBV) genotype C is more frequently linked to severe liver disease, including cirrhosis and liver cancer, in Chinese patients compared to genotype B. However, genotype differences did not significantly impact acute-on-chronic liver failure occurrence.
Area of Science:
- Hepatology
- Virology
- Genetics
Background:
- Hepatitis B virus (HBV) infection remains a significant global health concern.
- Understanding the influence of HBV genotypes on disease progression is crucial for effective management.
Purpose of the Study:
- To investigate the association between HBV genotypes and the development of chronic and severe liver disease in a Chinese patient cohort.
- To analyze the correlation between HBV genotypes and virological/biochemical markers of liver disease.
Main Methods:
- Serum samples from 2922 HBV-infected Chinese patients were analyzed.
- HBV genotyping was performed using type-specific primers polymerase chain reaction.
- Virological markers, biochemical markers, and clinical classifications were assessed and compared across different HBV genotypes.
Main Results:
- HBV genotypes B and C were predominant (15.9% and 83.5%, respectively).
- Genotype C was significantly more prevalent in cirrhosis and hepatocellular carcinoma groups compared to genotype B.
- HBeAg-positive rates and viral loads were higher in genotype C patients with severe liver disease (cirrhosis, hepatocellular carcinoma) compared to genotype B.
Conclusions:
- HBV genotypes B and C are the main types in Chinese patients.
- HBV genotype C is associated with a higher risk of chronic infection, cirrhosis, and hepatocellular carcinoma compared to genotype B.
- While genotype did not significantly affect acute-on-chronic liver failure, genotype C infection correlated with more severe liver damage and higher viral loads in advanced disease stages.
Objective:
To explore the association between HBV genotype and chronic/severe liver disease with HBV infection in Chinese patients.
Methods:
Serum samples were collected from 2922 patients with HBV infection. HBV genotyping was performed with type-specific primers polymerase chain reaction, and the virological and biochemical markers were detected, which differences in the genotypes between various clinical types of HBV infection and liver function and virological markers between various HBV genotyping were analyzed.
Results:
The genotype B, C, BC combinations, D of 2922 patients with HBV infection accounted for 15.9%, 83.5%, 0.41%, 0.21% respectively. The ratio of genotype B in acute hepatitis group was higher (P = 0.003), which the ratio of genotype C in the cirrhosis group and the hepatocellular carcinoma group was higher (P = 0.000, 0.000). The difference in ratio of genotype C was not statistically significant between acute-on-chronic liver failure group and chronic hepatitis group. HBeAg-positive rate, viral load and liver function markers of B, C genotype group in acute hepatitis group and chronic hepatitis group were not significant different. HBeAg-positive rates of genotype C in acute-on-chronic liver failure group, cirrhosis group, hepatocellular carcinoma group were higher than that of genotype B (P = 0.000, 0.024, 0.003). Viral load of genotype C in hepatocellular carcinoma group was higher than that of genotype B (P = 0.025). Cholinesterase levels of genotype C in the acute-on-chronic liver failure group and the hepatocellular carcinoma group was lower than that of genotype B (P = 0.0004, 0.02).
Conclusion:
There were HBV genotype B, C, B/C combinations and D in Chinese patients with HBV infection, with genotype B and C being the major ones. Compared with HBV genotype B, genotype C in Chinese patients with HBV infection was more likely to chronic infection, evolved to cirrhosis and hepatocellular carcinoma, but genotype difference was not observed in occurrence of acute-on-chronic liver failure. Genotype was not significant effect in acute and chronic hepatitis B, but HBeAg-positive rate/viral load was higher and liver damage was more severe in severe and end-stage genotype C HBV infection patients.
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