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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Transition metal based anticancer drugs.

K Benjamin Garbutcheon-Singh1, Maxine P Grant, Benjamin W Harper

  • 1Nanoscale Organisation and Dynamics Group, School of Biomedical and Health Sciences, College of Health and Science, University of Western Sydney, Locked Bag 1797, Penrith South DC, 1797 NSW, Australia.

Current Topics in Medicinal Chemistry
|December 30, 2010
PubMed
Summary
This summary is machine-generated.

New metal compounds offer potential cancer treatments beyond platinum drugs. Research explores diverse metallic elements for novel anticancer agents with different mechanisms and resistance profiles.

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Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Materials Science

Background:

  • Cancer is a leading cause of death, particularly in aging populations, driving the need for new treatments.
  • Platinum-based drugs like cisplatin are effective but have limitations and associated toxicities.
  • Existing treatments necessitate the development of novel anticancer agents with distinct mechanisms of action and resistance profiles.

Purpose of the Study:

  • To explore the therapeutic potential of various metal complexes as anticancer agents.
  • To highlight metal compounds beyond platinum with promising anticancer activity.
  • To illustrate diverse strategies for designing novel anticancer metal complexes.

Main Methods:

  • Literature review of metal complexes with demonstrated anticancer activity.
  • Analysis of different design approaches for novel anticancer metal compounds.
  • Highlighting therapeutic potential based on chemical structure and mechanism.

Main Results:

  • Identified various metal complexes exhibiting significant anticancer activity.
  • Demonstrated that elements beyond platinum hold therapeutic promise.
  • Illustrated diverse synthetic and mechanistic strategies for anticancer metal complex development.

Conclusions:

  • Metal complexes represent a promising avenue for developing next-generation cancer therapeutics.
  • Exploring diverse metallic elements can overcome limitations of current platinum-based drugs.
  • Innovative design approaches are crucial for advancing metal-based cancer treatments.