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Updated: Jun 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Angiogenesis inhibitors in prostate cancer therapy
Eun-mi Yu1, Maneesh Jain, Jeanny B Aragon-Ching
1Division of Hematology and Oncology, Department of Medicine, George Washington University Medical Center, 2150 Pennsylvania Avenue, NW, Washington, DC 20037, USA.
Anti-angiogenic therapies show promise for metastatic castrate-resistant prostate cancer (mCRPC) by inhibiting tumor growth. Clinical trials are evaluating these agents, focusing on survival outcomes and potential biomarkers for improved treatment strategies.
Area of Science:
- Oncology
- Pharmacology
Background:
- Metastatic castrate-resistant prostate cancer (mCRPC) has limited therapeutic options.
- Anti-angiogenic mechanisms represent a novel approach to cancer treatment.
Purpose of the Study:
- To review clinical trial findings on anti-angiogenic agents in mCRPC.
- To discuss the translation of these findings into clinical practice and future directions.
Main Methods:
- Review of significant findings from clinical trials involving anti-angiogenic drugs in mCRPC.
- Identification of ongoing clinical trials and their outcome measures (tumor progression, overall survival).
Main Results:
- Several anti-angiogenic agents are under investigation with diverse mechanisms of action.
- Clinical trials are assessing the efficacy of these agents in mCRPC patients.
Conclusions:
- Angiogenesis inhibition holds promise for mCRPC treatment but faces challenges.
- Future implications, limitations, and the role of biomarkers in anti-angiogenic therapy are discussed.
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