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A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency

Won Seok Lee1, Young Sil Park

  • 1Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.

Korean Journal of Pediatrics
|December 31, 2010
PubMed

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven®) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.

Keywords:
Congenital factor VII deficiencyIntracranial hemorrhageNeonate

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