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A High Output Method to Isolate Cerebral Pericytes from Mouse

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A new possible function for placental pericytes.

Carolyn J P Jones¹, Gernot Desoye

¹Maternal and Fetal Health Research Centre, MAHSC, University of Manchester, St. Mary's Hospital, Manchester, UK. carolyn.jones@manchester.ac.uk

Cells, Tissues, Organs

|January 4, 2011

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Newly identified structures on human placental pericytes may help regulate fluid balance. This blebbing phenomenon is more prevalent in complicated pregnancies, suggesting a role in placental pathology.

Area of Science:

Cell Biology
Reproductive Biology
Pathology

Background:

Pericytes are crucial cells associated with endothelial cells, potentially involved in angiogenesis and vessel stabilization.
Understanding pericyte function is vital for placental development and pathology research.

Purpose of the Study:

To investigate previously undescribed structures associated with human placental terminal villus pericytes.
To analyze the prevalence of these structures in normal versus complicated pregnancies.

Main Methods:

Re-examination of over 1,100 archival micrographs of human placental tissue.
Semi-quantitative analysis of pericyte-associated structures and their correlation with placental pathology.

Main Results:

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Last Updated: Jun 5, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse

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Published on: January 14, 2020

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero

Published on: September 8, 2023

Previously undescribed outgrowths from pericytes, forming stromal vesicles via blebbing, were identified.
These blebbing structures were found in normal term pregnancies but were significantly more frequent in placentae from pregnancies complicated by diabetes, postmaturity, rhesus incompatibility, and pre-eclampsia.
Capillary abnormalities, including failure to form sinusoids, were associated with increased pericyte blebbing.

Conclusions:

The identified pericyte blebbing phenomenon may represent a mechanism for fluid homeostasis.
Impaired endothelial cell function in pathological pregnancies may lead to increased pericyte blebbing.
This finding offers new insights into placental development, vascular function, and pathological conditions affecting pregnancy.