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Updated: Jun 5, 2026

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
[Erythema multiforme-like reaction to para-phenylenediamine]
Carsten Sauer Mikkelsen1, Frederik Liljefred, Dorthe Bisgaard Mikkelsen
1Dermatologiskvenerologisk Afdeling, Odense Universitetshospital, Denmark. c.s.mikkelsen@hotmail.com
Abstract:
A case of a 15 year-old girl who developed an erythema multiforme-like reaction to para-phenylenediamine (PPD) after Henna tattoos is described. The patient was treated successfully with oral prednisolone and highly potent topical corticosteroids. The patient developed a long-lasting post-inflammatory hyperpigmentation. Potential hyperreactive response was prevented by applying the PPD patch for only 30 minutes, but still there was a significantly positive reaction. This case highlights the need to ban the use of para-phenylenediamine and its derivates in dyes.
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