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11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2,2-Dichloro-N-(3,5-dimethyl-phen-yl)-acetamide
Acta Crystallographica. Section E, Structure Reports Online
|January 5, 2011
Summary
The crystal structure of a dichloro-N-phenyl-acetamide derivative was determined. Molecules form infinite chains via N-H⋯O and C-H⋯O hydrogen bonding, similar to related acetanilides.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- The title compound, C(10)H(11)Cl(2)NO, belongs to the acetanilide class of organic molecules.
- Acetanilides exhibit diverse biological activities and structural motifs.
Purpose of the Study:
- To elucidate the detailed molecular and crystal structure of the title compound.
- To compare its structural features with known acetanilide derivatives.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- Structural comparison with related compounds was conducted.
Main Results:
- The crystal structure revealed similarities in bond parameters to various dichloro-N-phenyl-acetamide and other acetanilide compounds.
- The molecules are interconnected into infinite chains through specific hydrogen bonding interactions (N-H⋯O and C-H⋯O).
Conclusions:
- The hydrogen bonding network dictates the formation of one-dimensional chains in the title compound.
- The structural findings contribute to understanding structure-property relationships in acetanilide derivatives.
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