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Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
Published on: November 16, 2018
Dental follicle stem cells and tissue engineering.
Masaki J Honda1, Mari Imaizumi, Shuhei Tsuchiya
1Department of Anatomy, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan. honda-ms@dent.nihon-u.ac.jp
Journal of Oral Science
|January 6, 2011
Summary
Dental follicle stem cells offer a promising source for mesenchymal stem cells from extracted impacted teeth. These cells show potential for tissue engineering, particularly in periodontal and bone regeneration applications.
Area of Science:
- Stem Cell Biology
- Regenerative Medicine
- Dental Tissue Engineering
Background:
- Adult stem cells are crucial for tissue regeneration and can differentiate into various cell types.
- Mesenchymal stem cells (MSCs) are found in various tissues, including dental tissues like the dental follicle.
- The dental follicle, surrounding developing teeth, is a potential source of MSCs.
Purpose of the Study:
- To review current knowledge on dental follicle stem cells (DFSCs).
- To highlight recent developments and applications of DFSCs in tissue engineering.
- To explore the potential of DFSCs as a readily available source of MSCs.
Main Methods:
- Literature review of studies on dental follicle stem cells.
- Analysis of stem cell characteristics and differentiation potential.
- Examination of applications in periodontal and bone regeneration.
Main Results:
- DFSCs possess multipotent characteristics, similar to other MSCs.
- DFSCs can be isolated from impacted teeth, often discarded as medical waste.
- Characterization studies indicate significant potential for DFSCs in regenerative applications.
Conclusions:
- Dental follicle stem cells represent a valuable and accessible cell source for regenerative medicine.
- DFSCs hold promise for future applications in periodontal and bone tissue engineering.
- Further research can optimize the use of DFSCs in clinical settings.
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