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Related Experiment Video

Updated: Jun 5, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Interplay between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism.

L Gianotti¹, A Piovesan, C G Croce

¹Division of Endocrinology and Metabolism, S. Croce & Carle Hospital, Cuneo, Italy. laura.gianotti@unito.it

Calcified Tissue International

|January 6, 2011

Summary

In primary hyperparathyroidism (PHPT), high osteocalcin (OC) levels are linked to insulin resistance. While OC predicts insulin sensitivity in PHPT, its normalization post-surgery without improved insulin sensitivity suggests a minor role.

Related Experiment Videos

Last Updated: Jun 5, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

Endocrinology
Metabolic Disorders
Bone Metabolism

Background:

Osteocalcin (OC) is implicated in regulating insulin sensitivity.
Primary hyperparathyroidism (PHPT) is associated with elevated OC and insulin resistance.

Purpose of the Study:

To investigate the relationship between osteocalcin levels and insulin resistance markers in PHPT patients.
To assess if this relationship persists after parathyroidectomy (PTX).

Main Methods:

Serum OC, fasting insulin, and glucose levels were measured in 219 PHPT patients.
Insulin sensitivity was estimated using homeostatic model assessment (HOMA2-S%).
Parameters were re-evaluated in 45 patients post-PTX.

Main Results:

PHPT patients exhibited high OC levels, which were lower in diabetics compared to normal or impaired glucose tolerance groups.
OC showed a negative association with fasting glucose and a positive association with HOMA2-S%.
Post-PTX, OC levels decreased, but HOMA2-S% remained unchanged.

Conclusions:

Osteocalcin is a predictor of insulin sensitivity in PHPT.
The lack of change in insulin sensitivity after OC normalization post-PTX suggests OC may not be a major driver of insulin resistance in PHPT.