Related Experiment Video
Updated: Jun 5, 2026
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
Published on: August 22, 2011
[Expression of c-jun mRNA in brain stem following moderate lateral fluid percussion brain injury in rats]
1Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China.
Aim:
To study the expression of c-jun in brain stem following moderate lateral fluid percussion brain injury in rats, and to observe the temporal patterns of its expressions following percussion.
Methods:
Male Sprague-Dawley rats were divided into normal control, sham operation control and injury groups. The rats of injury group subjected to moderate lateral fluid percussion injury (0.2MPa), and then were subdivided into 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h and 12 h groups according to the time elapsed after injury. The expression of c-jun was studied by immunohistochemistry and in situ hybridization.
Results:
After percussion for 15 min, Jun positive neurons increased in brain stem progressively. At 5 min after percussion, the induction of c-jun mRNA was increased, remained elevated up to 2h after brain injury and then decreased gradually.
Conclusion:
The induction and expression of the c-jun in brain stem after fluid percussion brain injury were increased rapidly and lasted for a long time.
