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Updated: Jun 5, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

The tumor microenvironment in colorectal carcinogenesis

Vijay G Peddareddigari, Dingzhi Wang, Raymond N Dubois

    Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
    |January 7, 2011
    PubMed

    Insights

    Colorectal cancer remains incurable despite advances. Research now focuses on the tumor microenvironment, exploring stromal components to develop new therapeutic strategies for better patient outcomes.

    Area of Science:

    • Oncology
    • Cancer Biology
    • Tumor Microenvironment Research

    Background:

    • Colorectal cancer is a leading cause of cancer mortality in the U.S.
    • Metastatic colorectal cancer remains largely incurable despite recent therapeutic advancements.
    • Many promising experimental cancer agents have failed to improve patient survival in clinical trials.

    Purpose of the Study:

    • To review the role of the tumor microenvironment in colorectal cancer progression.
    • To discuss the potential of targeting stromal components for novel colorectal cancer therapies.

    Main Methods:

    • Literature review of studies on tumor microenvironment and colorectal cancer.
    • Analysis of interactions between tumor epithelial cells and stromal elements.

    Main Results:

    • The tumor microenvironment significantly influences colorectal cancer progression.
    • Stromal components play a critical role in colorectal carcinogenesis.

    Conclusions:

    • Understanding tumor microenvironment interactions is crucial for improving colorectal cancer treatment.
    • Targeting stromal components offers a promising avenue for developing future therapeutic agents.
    Keywords:
    Colon cancerExtracellular matrixStromaTumor infiltrating cellsTumor microenvironment

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