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Published on: September 6, 2024
C-reactive protein in acute pulmonary embolism
Yasin Abul1, Sait Karakurt, Beste Ozben
1Ministry of Health Bismil Government Hospital, Pulmonary Medicine Clinics, Diyarbakir, Turkey.
Summary
C-reactive protein (CRP) shows prognostic value in acute pulmonary embolism (PE), correlating with right ventricular dysfunction. While not superior to NT-proBNP, CRP may aid in risk stratification for PE patients.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Biomarker Research
Background:
- Right ventricular dysfunction and NT-proBNP are established prognostic markers in acute pulmonary embolism (PE).
- The prognostic utility of C-reactive protein (CRP) in PE requires further investigation.
Purpose of the Study:
- To evaluate the prognostic value of C-reactive protein (CRP) in patients with acute pulmonary embolism (PE).
- To assess the association between CRP levels and right ventricular dysfunction in PE.
Main Methods:
- Fifty-six acute PE patients were enrolled and followed for 36 months.
- Serum levels of CRP, NT-proBNP, and troponin T were measured.
- Right ventricular function was assessed using transthoracic echocardiography.
Main Results:
- Higher CRP and NT-proBNP levels were associated with right ventricular dysfunction (P=0.020 and P=0.045).
- Mortality rates were higher with elevated CRP and troponin T, though not statistically significant.
- Cutoff values for NT-proBNP (1800 pg/mL) and CRP (48 mg/L) predicted mortality in PE patients.
Conclusions:
- C-reactive protein (CRP) is linked to right ventricular dysfunction, a key prognostic factor in PE.
- CRP may serve as a valuable biomarker for risk stratification in acute pulmonary embolism.
- CRP's prognostic capability in PE is comparable to NT-proBNP but not superior.
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