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Development of Multiplex Real-Time RT-qPCR Assays for the Detection of SARS-CoV-2, Influenza A/B, and MERS-CoV
Published on: November 10, 2023
Epidemiology and Clinical Presentation of COVID-19 in Older Adults
Yasin Abul1, Ciera Leeder2, Stefan Gravenstein1
1Center of Innovation in Long Term Services and Supports, Providence VA Medical Center, Providence, RI, USA; Division of Geriatric and Palliative Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA; Brown University, School of Public Health Center for Gerontology, Healthcare Research.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains asymptomatic in 33% to 90% of older adults depending on their immune status from prior infection, vaccination, and circulating strain. Older adults symptomatic with SARS-CoV-2 often both present atypically, such as with a blunted fever response, and develop more severe disease. Early and late reports showed that older adults have increased severity of coronavirus disease 2019 (COVID-19) with higher case fatality rates and higher intensive care needs compared with younger adults. Infection and vaccine-induced antibody response and long-term effects of COVID-19 also differ in older adults.
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