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Glucosamine and chondroitin sulfate
Karla L Miller1, Daniel O Clegg
1Division of Rheumatology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA. Karla.Miller@hsc.utah.edu
Rheumatic Diseases Clinics of North America
|January 12, 2011
Summary
Glucosamine and chondroitin sulfate supplements are popular for osteoarthritis. Clinical trial data on their efficacy and safety for managing osteoarthritis symptoms and disease progression is reviewed.
Area of Science:
- Biochemistry and Molecular Biology
- Orthopedics and Sports Medicine
- Nutritional Science
Background:
- Glucosamine and chondroitin sulfate are natural cartilage components.
- Osteoarthritis (OA) is prevalent, with limited effective therapies.
- These supplements are widely marketed for OA treatment.
Purpose of the Study:
- To evaluate the potential role of glucosamine and chondroitin sulfate in osteoarthritis treatment.
- To review clinical trial data on the efficacy and safety of these supplements for OA management.
- To assess their impact on OA symptoms and disease progression.
Main Methods:
- Review of relevant clinical trial data.
- Summary of efficacy and safety findings.
- Inclusion of pharmacokinetic and bioavailability data where available.
Main Results:
- Clinical trial data on efficacy and safety was reviewed.
- Information on symptom management and disease modification was assessed.
- Limited pharmacokinetic and bioavailability data was noted.
Conclusions:
- Glucosamine and chondroitin sulfate are of substantial interest for osteoarthritis management.
- Clinical trial evidence on their therapeutic role requires careful review.
- Further research may be needed to clarify their benefits in osteoarthritis.
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