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Updated: Jun 5, 2026
Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
Published on: September 8, 2023
Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-Tesla magnetic resonance
Gregory Chang1, Ligong Wang, Guoyuan Liang
1Center for Biomedical Imaging, Department of Radiology, 660 First Avenue, 4th Floor, NYU Langone Medical Center, New York, NY 10016, USA. gregory.chang@nyumc.org
Abstract:
High-resolution magnetic resonance imaging (MRI) of trabecular bone combined with quantitative image analysis represents a powerful technique to gain insight into trabecular bone micro-architectural derangements in osteoporosis and osteoarthritis. The increased signal-to-noise ratio of ultra high-field MR (≥7 Tesla) permits images to be obtained with higher resolution and/or decreased scan time compared to scanning at 1.5/3T. In this small feasibility study, we show high measurement precision for subregional trabecular bone micro-architectural analysis performed on 7T knee MR images. The results provide further support for the use of trabecular bone measures as biomarkers in clinical studies of bone disorders.
