Interictal epileptiform discharges and asystole
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Updated: Jun 5, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Maromi Nei1, Andro T Zangaladze, Ashwini Sharan
1Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, United States. Maromi.Nei@jefferson.edu
Abstract:
We describe a case of a patient with Lennox-Gastaut syndrome who had asystole and sinus bradycardia during interictal epileptiform abnormalities on EEG. Video-EEG/EKG monitoring prior to corpus callosotomy recorded consistent prolongation of the R-R interval on the EKG during bursts of epileptiform abnormalities (generalized paroxysmal fast activity), which became transiently more pronounced after surgery. These findings reveal that interictal epileptiform abnormalities may cause significant cardiac arrhythmias in some individuals.
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