Related Experiment Video
Updated: Jun 5, 2026
Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
Published on: March 1, 2017
Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods
Mabel Enriquez-Algeciras1, Di Ding, Tsung-Han Chou
1Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA.
Purpose:
To evaluate the ND4 transgenic mouse model of multiple sclerosis using noninvasive methods.
Methods:
Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis.
Results:
Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities.
Conclusions:
The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.
