Related Experiment Video
Updated: Jun 5, 2026

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs
Published on: August 15, 2025
Molecular mechanism of long-chain fatty acid uptake
Abstract:
Most eukaryotic cells are capable of taking up long-chain fatty acids (LCFAs) to be used for a variety of cellular processes. Low levels of cellular uptake may occur by simple diffusion of these hydrophobic molecules through the plasma membrane. However, tissues such as cardiac muscle and fat specifically and efficiently take up and release LCFAs in a regulated fashion. In cardiac myocytes and adipocytes, a recently described integral plasma membrane fatty acid transport protein (FATP) functions as an LCFA transporter. FATP may play a role in abnormalities o f LCFA uptake and metabolism in cardiac pathophysiology.
Related Concept Videos
Receptor-mediated Endocytosis
Receptor-mediated Endocytosis
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-Mediated Endocytosis
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Drug Absorption Mechanism: Passive Membrane Transport

