Effects of 5-HT2A receptor stimulation and blocking on immune response
S M Davydova1, M A Cheido, M M Gevorgyan
1Laboratory of Neurochemical Modulation Mechanisms, Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.
Abstract:
Experiments on CBA mice showed that selective stimulation of 2A serotonin receptors with DOI agonist (1 mg/kg) led to suppression of the immune response and reduction of the spleen and peripheral blood CD8(+)T cell counts with the cytotoxic/suppressor function. Selective blockade of these receptors with ketanserin (1 mg/kg) had an opposite effect: immunostimulation with an increase in CD8(+)T cell count in the spleen. These data indicate the involvement of 2A serotonin receptors in immunosuppressive mechanisms of serotoninergic system.
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