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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation01:38

Inflammation

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Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

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Bone Remodeling01:40

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Fractures: Bone Repair01:27

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Related Experiment Video

Updated: Jun 5, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Infection, inflammation, and bone regeneration: a paradoxical relationship.

M V Thomas1, D A Puleo

  • 1Department of Oral Health Practice, University of Kentucky College of Dentistry, 800 Rose Street, Room D-124, Lexington, KY 40536-0297, USA. mvthom0@uky.edu

Journal of Dental Research
|January 21, 2011
PubMed
Summary

Inflammation

Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Craniofacial surgery

Background:

  • Craniofacial bone regeneration often uses implants, which can become infected.
  • Infections lead to inflammation and tissue destruction, potentially hindering bone healing.
  • The role of inflammation in bone healing is complex and context-dependent.

Purpose of the Study:

  • To explore the dual role of inflammation in craniofacial bone regeneration.
  • To understand how persistent inflammation from infected implants affects bone healing.
  • To investigate the temporal dynamics of inflammatory mediators in bone repair.

Main Methods:

  • Literature review on bone regeneration strategies and inflammatory responses.
  • Analysis of the mechanisms linking microbial biofilms, inflammation, and tissue destruction.

Related Experiment Videos

Last Updated: Jun 5, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

  • Examination of the temporal sequence of inflammatory mediator expression during bone healing.

    • Main Results:

    • Inflammation is essential for initiating bone healing but can impede it if prolonged.
    • Infected implants can cause persistent inflammation, leading to suboptimal bone formation.
    • The timing of inflammatory mediator expression critically influences regenerative outcomes.

    Conclusions:

    • Optimizing craniofacial bone regeneration requires understanding the temporal context of inflammation.
    • Managing inflammation is key to successful outcomes, especially with implantable materials.
    • Targeting the temporal sequence of inflammatory events may enhance bone healing.