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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: Jun 5, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic aberrations during oncogenesis.

Maria Hatziapostolou1, Dimitrios Iliopoulos

  • 1Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Cellular and Molecular Life Sciences : CMLS
|January 21, 2011
PubMed
Summary

Cancer cells exhibit altered epigenetic patterns, including DNA methylation and histone modifications. Understanding the interplay between genetics, epigenetics, and microRNAs is crucial for developing targeted cancer therapies.

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer cells display a distinct epigenetic landscape, including global hypomethylation and tumor suppressor gene hypermethylation.
  • MicroRNA expression is epigenetically controlled, and microRNAs can influence epigenetic regulators.
  • The dynamic nature of epigenetic modifications enables the development of epigenetic-altering drugs.

Purpose of the Study:

  • To explore the intricate relationship between genetics, epigenetics, and microRNAs in cancer.
  • To identify therapeutic targets for correcting gene expression aberrations in tumorigenesis.

Main Methods:

  • Review of current literature on cancer epigenetics and microRNA regulation.
  • Analysis of epigenetic mechanisms in tumor suppressor gene regulation.
  • Investigation of microRNA's role in modulating the epigenetic machinery.

Main Results:

  • Aberrant epigenetic modifications are hallmarks of cancer cells.
  • MicroRNAs are integral components of the epigenetic regulatory network in cancer.
  • Epigenetic reversibility offers a window for therapeutic intervention.

Conclusions:

  • A comprehensive understanding of the genetics-epigenetics-microRNA axis is essential for effective cancer treatment.
  • Targeting the epigenetic machinery offers a promising strategy for cancer therapy.