Related Experiment Video
Updated: Jun 5, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity
Yuhui Huang1, Matija Snuderl, Rakesh K Jain
1Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Abstract:
Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.
Related Concept Videos
The Tumor Microenvironment
The Tumor Microenvironment
Tumor Immunotherapy
