Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral clonal elimination of functional T cells.

L A Jones1, L T Chin, D L Longo

  • 1Biological Response Modifiers Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Science (New York, N.Y.)
|December 21, 1990
PubMed
Summary

Developing T cell tolerance is crucial for preventing autoimmunity. This study reveals a novel extrathymic mechanism involving the elimination of mature T cells that recognize self antigens, complementing known thymic deletion processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commonly used mouse strains.

Current protocols in immunology·2008
Same author

Isolation of mouse mononuclear cells.

Current protocols in immunology·2008
Same author

In vivo depletion of CD4- and CD8-specific T cells.

Current protocols in immunology·2008
Same author

Circumventing T-cell tolerance to tumour antigens.

Biologicals : journal of the International Association of Biological Standardization·2002
Same author

Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Low-avidity self-specific T cells display a pronounced expansion defect that can be overcome by altered peptide ligands.

Journal of immunology (Baltimore, Md. : 1950)·2001

Area of Science:

  • Immunology
  • T cell biology
  • Self-tolerance mechanisms

Background:

  • Intrathymic clonal deletion is a primary mechanism for T cell tolerance to self antigens presented by hematopoietic cells.
  • Mechanisms of tolerance induction to antigens not expressed in the thymus are not fully understood.
  • Extrathymic tolerance can be induced via clonal nonresponsiveness in T cells with self-reactive receptors.

Purpose of the Study:

  • To elucidate mechanisms of extrathymic tolerance induction.
  • To identify novel pathways for generating tolerance to self antigens absent in the thymus.
  • To investigate the fate of mature T cells with self-reactive receptors.

Main Methods:

  • Analysis of T cell populations and their reactivity.
  • Investigating extrathymic tolerance induction pathways.

Related Experiment Videos

  • Characterizing mechanisms of clonal elimination in mature T cells.

    • Main Results:

    • A second mechanism of extrathymic tolerance was identified.
    • This mechanism involves the clonal elimination of mature T cells.
    • These eliminated T cells possess self-reactive receptors and had previously shown functional reactivity.

    Conclusions:

    • Extrathymic tolerance can be established through clonal elimination of mature, reactive T cells.
    • This pathway complements intrathymic deletion for maintaining self-tolerance.
    • Understanding these mechanisms is vital for autoimmune disease research.