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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Commonly used mouse strains.

A M Kruisbeek¹

¹Netherlands Cancer Institute, Amsterdam, The Netherlands.

Current Protocols in Immunology

|April 25, 2008

Summary

This summary is machine-generated.

This appendix details common mouse strains and their cell-surface molecules, focusing on H-2 loci encoding major histocompatibility complex (MHC) proteins. It also describes congenic strains, crucial for understanding MHC glycoproteins in immunology.

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Area of Science:

Immunology
Genetics
Animal Models

Background:

Mice are vital models in immunological research.
The H-2 locus on chromosome 17 encodes major histocompatibility complex (MHC) proteins.
Specific H-2 loci (Aa, Ab, Ea, Eb, K, D) are critical for immune interactions.

Purpose of the Study:

To provide a reference for commonly used mouse strains and their cell-surface molecules.
To detail H-2 loci and other immunologically significant genes.
To list congenic strains and those with intra-H-2 recombination events.

Main Methods:

Compilation of data on mouse strains and their genetic loci.
Identification of H-2 loci encoding MHC class I and class II molecules.
Description of congenic strain derivation and intra-H-2 recombination.

Main Results:

A comprehensive list of commonly used mouse strains and their H-2 loci.
Inclusion of immunologically important genes beyond H-2.
Identification of congenic strains differing at the H-2 locus and strains with intra-H-2 recombination.

Conclusions:

The listed mouse strains, particularly congenic strains, are invaluable resources.
Understanding H-2 complex variations is key to defining MHC glycoprotein roles.
This appendix serves as a critical reference for immunological studies.