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Updated: Jun 5, 2026
A Multimodal Wide-Field Fourier-Transform Raman Microscope
Published on: December 30, 2025
Enhanced bioanalyte detection in waveguide confined Raman spectroscopy using wavelength modulation
Praveen C Ashok1, Anna Chiara De Luca, Michael Mazilu
1SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St. Andrews, Fife, Scotland, KY16 9SS, UK. pca7@st-andrews.ac.uk
Abstract:
Waveguide confined Raman spectroscopy (WCRS) incorporates a fibre based Raman detection system in a microfluidic platform enabling the spectroscopic detection of analyte. It offers the possibility to develop portable, alignment free devices for bio-analyte sensing with minimal sample preparation. Ultimate sensitivity is limited by the fibre auto-fluorescence background. Here we report enhanced bio-analyte detection sensitivity by combining WCRS with continuous wavelength modulation technique. We used urea as a model analyte and the modulation parameters have been optimized to maximize the sensitivity of the device.
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