Related Experiment Video
Updated: Jun 5, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
Published on: November 21, 2017
Multinuclear Pd/Zn complex-catalyzed asymmetric alkylative ring-opening reaction of oxabicyclic alkenes
Kohei Endo1, Keisuke Tanaka, Mika Ogawa
1Waseda Institute for Advanced Study, Shinjuku, Tokyo, Japan. kendo@aoni.waseda.jp
Abstract:
A multinuclear palladium catalyst can be used to realize the efficient catalytic asymmetric alkylative ring-opening reaction of oxabicyclic alkenes using dimethylzinc. The use of (R)-BINOL-PHOS bearing bisphosphine and diol moieties is essential for achieving excellent catalytic performance; the corresponding monophosphine and hydroxy-protected derivatives showed lower catalytic activities and/or enantioselectivities. The generation of Pd/Zn-multinuclear complexes is a key feature of the present catalysis.
Related Concept Videos
Base-Catalyzed Ring-Opening of Epoxides
Acid-Catalyzed Ring-Opening of Epoxides
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Radical Anti-Markovnikov Addition to Alkenes: Mechanism
The mechanism starts with chain initiation, which involves two steps. In the first chain initiation step, a weak peroxide bond is homolytically cleaved upon mild heating to form two alkoxy radicals. In the second initiation step, a hydrogen atom is abstracted by the alkoxy radical...
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

