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Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in

Makoto Saito1, Kazunori Nishimura, Hiroki Nozue

  • 1Department of Pediatrics, University of Tsukuba, Tsukuba, Japan.

Neonatology
|January 29, 2011
PubMed

Insights

Serum adiponectin levels increase in preterm infants. Higher adiponectin levels at term-equivalent age correlate with better postnatal growth in appropriate-for-gestational-age infants compared to small-for-gestational-age infants.

Area of Science:

  • Neonatal physiology
  • Endocrinology
  • Growth and Development

Background:

  • Adiponectin, an adipocytokine, is crucial for fetal growth and insulin sensitivity.
  • Its role in preterm infant development requires further investigation.

Purpose of the Study:

  • To investigate the relationship between intrauterine and postnatal growth patterns and adiponectin secretion in preterm infants.
  • To compare adiponectin levels in appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) preterm infants.

Main Methods:

  • Serum adiponectin concentrations were measured in 30 AGA and 19 SGA preterm infants at birth and term-equivalent age.
  • Statistical analyses included comparisons between groups and correlation with growth parameters.

Main Results:

  • Adiponectin levels significantly increased from birth to term-equivalent age in all preterm infants.
  • Term-equivalent adiponectin levels were higher in AGA infants than SGA infants (p < 0.01).
  • The increase in adiponectin levels correlated positively with weight gain rate (r = 0.37, p < 0.01), which was the sole independent predictor.

Conclusions:

  • Changes in serum adiponectin levels reflect postnatal growth in preterm infants.
  • Adiponectin may serve as a biomarker for monitoring growth in preterm neonates.
Abstract

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