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Updated: Jun 4, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

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Published on: March 14, 2019

The Evi1, microRNA-143, K-Ras axis in colon cancer

Jin-Song Gao1, Yingjie Zhang, Xiaoli Tang

  • 1Division of Infectious Diseases, Department of Medicine, Miriam and Rhode Island Hospitals, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

FEBS Letters
|February 1, 2011
PubMed

Insights

The ecotropic viral integration site 1 oncoprotein (Evi1) suppresses miRNA-143, a gene underexpressed in colon cancer. This study reveals a molecular axis linking Evi1 and miRNA-143 in human colon cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • MicroRNA (miRNA) expression signatures are linked to various diseases, including cancers.
  • Colon cancer exhibits underexpression of miRNA-143, but the underlying molecular mechanisms remain unclear.
  • The K-Ras oncogene is a known target of miRNA-143.

Purpose of the Study:

  • To investigate the molecular etiology behind miRNA-143 underexpression in colon cancer.
  • To identify regulatory factors controlling miRNA-143 gene expression.
  • To elucidate the relationship between Evi1 and miRNA-143 in the context of human colon cancer.

Main Methods:

  • Analysis of microRNA expression profiles in diseased and non-diseased tissues.
  • Investigating the transcriptional regulation of the miRNA-143 gene.
  • Assessing the relationship between Evi1 and miRNA-143 expression levels.

Main Results:

  • The ecotropic viral integration site 1 oncoprotein (Evi1) acts as a transcriptional suppressor of the miRNA-143 gene.
  • An indirect molecular relationship between Evi1 and miRNA-143 expression was identified.
  • A complex molecular axis involving Evi1 and miRNA-143 is active in human colon cancer.

Conclusions:

  • Evi1 plays a critical role in suppressing miRNA-143 expression.
  • The Evi1-miRNA-143 axis represents a significant molecular pathway in human colon cancer pathogenesis.
  • Understanding this axis may offer new therapeutic targets for colon cancer.

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