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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jun 4, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

MRI in experimental stroke.

Timothy Q Duong1

  • 1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. duongt@uthscsa.edu

Methods in Molecular Biology (Clifton, N.J.)
|February 1, 2011
PubMed
Summary
This summary is machine-generated.

Advanced MRI techniques like diffusion-weighted imaging (DWI) can rapidly detect acute stroke injury. This allows for timely intervention to salvage brain tissue and potentially reduce long-term disability from stroke.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Stroke is a leading cause of death and disability.
  • Ischemic stroke involves a core of severe injury surrounded by a penumbra of potentially salvageable tissue.
  • Timely intervention is crucial for salvaging ischemic brain tissue.

Purpose of the Study:

  • To describe stroke modeling techniques.
  • To explain advanced MRI methods for acute stroke imaging.
  • To detail image analysis for experimental stroke studies.

Main Methods:

  • Utilizing magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping.
  • Employing quantitative perfusion imaging to assess cerebral blood flow (CBF).
  • Defining the perfusion-diffusion mismatch to approximate the ischemic penumbra.

Main Results:

  • DWI can detect ischemic injury within minutes, outperforming other modalities.
  • Perfusion-diffusion mismatch quantifies the ischemic penumbra non-invasively.
  • Advanced MRI techniques enable early and accurate stroke diagnosis.

Conclusions:

  • Rapid detection of ischemic injury using DWI-MRI is critical for acute stroke management.
  • The perfusion-diffusion mismatch is a valuable imaging biomarker for identifying salvageable brain tissue.
  • This chapter provides a comprehensive overview of imaging techniques for experimental stroke research.