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Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
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Spirometric indices after bronchodilator test in obstructive lung disease.

Amir Houshang Mehrparvar1, Seyed Jalil Mirmohammadi, Mohammad Mehdi Sohrabi

  • 1Department of Occupational Medicine, Shahid Rahnamoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ahmehrparvar@ssu.ac.ir

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Assessing bronchodilator response in obstructive lung disease is crucial. The study found Forced Expiratory Volume in 1 second (FEV1) to be the most reliable spirometric index for determining bronchial reversibility.

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Bronchial responsiveness testing is essential for diagnosing reversible airflow obstruction.
  • Spirometry indices like FEV1, FEF(25-75%), and FVC are commonly used to assess bronchodilator response.

Purpose of the Study:

  • To evaluate and compare the reliability of different spirometric indices in assessing bronchodilator response in workers with obstructive spirometry patterns.
  • To determine the prevalence of bronchial reversibility in this population.

Main Methods:

  • A cross-sectional study involving 187 workers with obstructive spirometry patterns.
  • Spirometric measurements were taken before and after bronchodilator administration.
  • Responsiveness was defined by a 200 cc and 12% increase in FEV1 or FVC.

Main Results:

  • 35.8% of participants showed a significant bronchodilator response.
  • Forced Expiratory Volume in 1 second (FEV1) was the most frequently increased index among responsive cases.
  • Peak Expiratory Flow (PEF) and Forced Vital Capacity (FVC) were least frequently increased; FEF75% showed the highest mean increase.

Conclusions:

  • Forced Expiratory Volume in 1 second (FEV1) is the most reliable spirometric index for assessing bronchodilator response.
  • Bronchial reversibility demonstrates an inverse relationship with baseline spirometric measures, suggesting poorer reversibility with more severe obstruction.