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[Influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B]

Yu-lin Zhou1, Xue-cai Wang, Yin-tao Wu

  • 1Department of Infectious Diseases, Yixing People's Hospital 214200, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|February 2, 2011
PubMed

Insights

Adefovir dipivoxil treatment increased HBV specific cellular immunity in chronic hepatitis B patients. This antiviral therapy also significantly reduced HBV DNA levels, with many patients achieving undetectable viral loads.

Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Chronic hepatitis B (CHB) is a persistent viral infection.
  • HBV specific cellular immunity plays a crucial role in controlling HBV infection.
  • Adefovir dipivoxil is an antiviral medication used in CHB management.

Purpose of the Study:

  • To investigate the impact of adefovir dipivoxil on HBV specific T-cell responses in CHB patients.
  • To assess the correlation between adefovir dipivoxil treatment and viral load reduction.

Main Methods:

  • Adefovir dipivoxil (10 mg daily) was administered to CHB patients with detectable HBV DNA and elevated ALT.
  • Real-time quantitative PCR was used to measure HBV DNA levels.
  • Flow cytometry assessed HBV specific cytotoxic T-lymphocyte (CTL) responses and HLA-A2 expression.

Main Results:

  • Adefovir dipivoxil treatment significantly increased HBV specific CTL levels compared to baseline (0.52% vs. 0.34%, P < 0.01).
  • 62.22% of patients achieved undetectable HBV DNA after 3 months of treatment.
  • Remaining patients showed a significant reduction in HBV DNA levels (4.18 log10 copies/ml vs. 6.23 log10 copies/ml, P < 0.01).

Conclusions:

  • Adefovir dipivoxil enhances HBV specific cellular immunity in CHB patients.
  • The drug effectively suppresses viral replication, leading to significant reductions in HBV DNA.
  • These findings support adefovir dipivoxil's role in improving immune control of CHB.
Abstract

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