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Related Concept Videos

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

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The DNA Helix01:16

The DNA Helix

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The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Updated: Jun 4, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Two-dimensional DNA origami assemblies using a four-way connector.

Masayuki Endo1, Tsutomu Sugita, Arivazhagan Rajendran

  • 1Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan. endo@kuchem.kyoto-u.ac.jp

Chemical Communications (Cambridge, England)
|February 3, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel four-way DNA connector enabling two-dimensional self-assembly. This innovation successfully created complex cruciate and hollow square DNA origami structures from multiple monomers.

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Area of Science:

  • Nanotechnology
  • Biomolecular Engineering
  • Materials Science

Background:

  • DNA origami is a powerful technique for nanoscale fabrication.
  • Existing methods often face limitations in creating complex 2D structures.

Purpose of the Study:

  • To develop a versatile connector for advanced DNA origami self-assembly.
  • To demonstrate the formation of complex 2D structures using the novel connector.

Main Methods:

  • Design and synthesis of a DNA connector with connection sites on all four edges.
  • Utilizing the four-way connector for directed self-assembly of DNA origami monomers.
  • Characterization of the assembled structures.

Main Results:

  • Successful two-dimensional self-assembly of DNA origami structures was achieved.
  • Five monomers were assembled into a cruciate structure.
  • Eight monomers were assembled into a hollow square structure.

Conclusions:

  • The four-way DNA connector is effective for creating complex 2D DNA origami architectures.
  • This method offers a new pathway for designing intricate nanostructures.
  • The developed connector enhances the versatility of DNA self-assembly.