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Mechanisms of fluid-flow-induced matrix production in bone tissue engineering

H L Morris1, C I Reed, J W Haycock

  • 1Department of Engineering Materials, Kroto Research Institute, University of Sheffield, Broad Lane, UK.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|February 4, 2011
PubMed
Summary

Fluid flow stimulates bone matrix production, with hyaluronan (HA) and CD44 mediating this process in tissue engineering. These molecules are crucial for collagen production but not short-term NF-kappaB activation.

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