[Animal models for bone and joint disease. K/BxN mice - serum transferred arthritis -]

K/BxN mice spontaneously develop severe symmetrical polyarthritis, and serum from these mice induces a similar arthritis in a wide range of mouse strains, due to autoantibodies recognizing glucose-6-phosphate isomerase (GPI) . K/BxN mice and their serum have been used for investigating the development of arthritis, particularly used for analyzing how autoantibody recognizing GPI directly induce systemic arthritis. This section summarizes the mechanisms of autoimmune arthritis of K/BxN mice, and discusses future direction.