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Cannabinoids: potential targets for bladder dysfunction.

Michael R Ruggieri1

  • 1Temple University School of Medicine, Philadelphia, PA 19140-5104, USA. rugg101@verizon.net

Handbook of Experimental Pharmacology
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

Cannabinoids, active cannabis components, impact the lower urinary tract. Further research into cannabinoid receptors is needed for developing new treatments for pelvic disorders.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Urology

Background:

  • Cannabinoids are active compounds in Cannabis sativa with a long history of medical use.
  • Cannabinoid receptors are targets for pharmaceutical development to harness therapeutic benefits while mitigating psychotropic effects.
  • Cannabinoid receptors are implicated in both central and peripheral nervous system functions.

Purpose of the Study:

  • To provide an overview of cannabinoid pharmacology and derivatives.
  • To review the role of cannabinoid receptors in lower urinary tract function.
  • To evaluate clinical trials of cannabis extracts for bladder dysfunction in multiple sclerosis.

Main Methods:

  • Literature review of cannabinoid pharmacology.
  • Analysis of studies on cannabinoid receptors in the lower urinary tract.
  • Evaluation of clinical trial data for cannabis in multiple sclerosis-related bladder dysfunction.

Main Results:

  • Cannabinoid receptors are present in the lower urinary tract, spinal cord, and higher brain centers controlling urinary function.
  • Systemic cannabinoids demonstrate effects on the lower urinary tract with potential clinical utility.
  • Evidence suggests a role for cannabinoids in managing bladder dysfunction, particularly in conditions like multiple sclerosis.

Conclusions:

  • Cannabinoid receptors are key components in the control of the human lower urinary tract.
  • Systemic cannabinoid administration shows promise for treating pelvic disorders.
  • Further investigation into the mechanisms of cannabinoid receptors is essential for developing targeted therapies for bladder dysfunction.