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Volatile Sex Pheromone Extraction and Chemoattraction Assay in Caenorhabditis elegans
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Is androstadienone a putative human pheromone?

D Marazziti1, P Torri, S Baroni

  • 1Dipartimento di Psichiatria Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, 56100 Pisa, Italy. dmarazzi@psico.med.unipi.it

Current Medicinal Chemistry
|February 5, 2011
PubMed
Summary
This summary is machine-generated.

Androstadienone, an axillary steroid, is debated as a human pheromone due to low experimental levels. This review examines evidence to determine its role in modulating human behavior.

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Area of Science:

  • Human pheromone research
  • Steroid biochemistry
  • Behavioral endocrinology

Background:

  • Androstadienone, a steroid compound from armpits, is proposed as a human pheromone.
  • Its physiological concentrations are often too low to elicit responses in experimental settings.
  • This leads to skepticism about its efficacy and consideration of axillary extracts as a whole.

Purpose of the Study:

  • To review existing data on androstadienone.
  • To evaluate its potential as a physiological human pheromone.
  • To assess its viability as a target for future behavioral modulators.

Main Methods:

  • Literature review of scientific evidence.
  • Analysis of studies on androstadienone's effects.
  • Synthesis of data on physiological concentrations and behavioral contexts.

Main Results:

  • Evidence suggests androstadienone's role as a pheromone is questionable at low physiological levels.
  • Alternative theories propose axillary extracts or context-dependent effects.
  • Varying potency and behavioral relevance at lower concentrations are considered.

Conclusions:

  • The role of androstadienone as a direct human pheromone remains uncertain.
  • Further research is needed to clarify its function and potential applications.
  • Its significance may lie in complex interactions within axillary compounds or specific contexts.