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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Updated: Jun 4, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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Update on cosmeceuticals.

Martina Kerscher1, Heike Buntrock

  • 1Department of Chemistry, Division of Cosmetic Science, University of Hamburg, Germany. martina.kerscher@uni-hamburg.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|February 5, 2011
PubMed
Summary
This summary is machine-generated.

This review covers new cosmeceutical developments, focusing on distinguishing them from cosmetics and drugs. It highlights active ingredients like antioxidants for skin aging and emphasizes evidence-based efficacy for quality assessment.

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Area of Science:

  • Dermatology
  • Cosmeceutical Science

Background:

  • Youth and beauty perception drive cosmeceutical market growth.
  • Distinguishing between cosmetics, cosmeceuticals, and drugs presents challenges.

Purpose of the Study:

  • To review new developments in cosmeceutical raw materials, carrier systems, and ingredients.
  • To focus on dermatological perspectives and active ingredients for skin aging.
  • To outline quality parameters for cosmeceuticals.

Main Methods:

  • Literature review of recent developments in cosmeceutical science.
  • Focus on dermatological evaluation of ingredients and systems.
  • Analysis of efficacy parameters (in-vivo, in-vitro).

Main Results:

  • New raw materials, carrier systems, and ingredients are emerging.
  • Antioxidants and cell regulators are key active ingredients for anti-skin-aging.
  • Evidence-based efficacy and scientifically proven effects are crucial for quality.

Conclusions:

  • Cosmeceuticals represent an evolving field with significant dermatological implications.
  • Quality assessment requires rigorous scientific validation of efficacy and safety.
  • Further research into novel ingredients and delivery systems is warranted.