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Correlation between stated and measured concentrations of acrylate and methacrylate allergens in patch-test
Anthony Teik-Jin Goon1, Magnus Bruze, Erik Zimerson
1Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden. anthonygoon@nsc.gov.sg
Background:
Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations.
Objective:
To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia.
Methods:
The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content.
Results:
Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated concentrations ranged from 0.11 to 1.1. Only 22 (63%) of 35 samples were within the arbitrary acceptable limits of 80 to 120% of the stated concentrations.
Conclusion:
The results may have implications for individual diagnosis and prevention and when test results from various centers are compared.
