Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency.

Genes & development·2026
Same author

Differences in Optic Pathway Glioma Prevalence Among Children with Neurofibromatosis Type 1.

The Journal of pediatrics·2026
Same author

Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.

The Journal of pediatrics·2026
Same author

Nested ecosystems theory for conceptualizing brain tumors.

Disease models & mechanisms·2026
Same author

Time trends in the male to female ratio for autism incidence: population based, prospectively collected, birth cohort study.

BMJ (Clinical research ed.)·2026
Same author

Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation.

Neuro-oncology advances·2026

Related Experiment Video

Updated: Jun 4, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

Rethinking pediatric gliomas as developmental brain abnormalities.

Nikkilina R Crouse1, Sonika Dahiya, David H Gutmann

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Current Topics in Developmental Biology
|February 8, 2011
PubMed
Summary

Neurofibromatosis type 1 (NF1) research reveals brain tumors are dynamic ecosystems. Interactions between non-cancerous and cancerous cells, supported by the microenvironment, are crucial for glioma growth.

More Related Videos

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jun 4, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Area of Science:

  • Oncology
  • Neuroscience
  • Genetics

Background:

  • Neurofibromatosis type 1 (NF1) is a genetic disorder predisposing individuals to tumors.
  • Brain tumor formation and growth are complex processes involving cellular interactions.

Purpose of the Study:

  • To review evidence supporting the concept of brain tumors as dynamic ecosystems.
  • To highlight the role of the microenvironment in glioma development.

Main Methods:

  • Review of experimental evidence on brain tumor formation.
  • Analysis of cellular interactions in neoplastic and non-neoplastic cells.

Main Results:

  • Brain tumors require a permissive microenvironment for neoplastic cell expansion.
  • Interactions between stromal and neoplastic cells dictate glioma formation and growth.

Conclusions:

  • Brain tumors are dynamic ecosystems influenced by cellular crosstalk.
  • Targeting these critical cellular relationships offers therapeutic strategies for gliomas.