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Updated: Jun 4, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Hypothyroidism, dilated cardiomyopathy and nephrotic syndrome during pregnancy]
Ariel K Saad1, Guillermo Lopez Soutric, Yael Nowicky
1División Cardiología, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires. aksaad@arnet.com.ar
Abstract:
Hypothyroidism during pregnancy is infrequent, but its presence is associated with maternal and fetal complications. We present the case of a young pregnant woman with no previous history of cardiovascular disease, who consulted for orthopnea, chest pain and edema in both legs. Laboratory tests demonstrated a hypothyroid condition and a nephrotic syndrome with renal failure. The echo-Doppler exam showed a four chamber dilatation with systolic dysfunction. Treatment with intravenous levothyroxine improved her medical condition. We analyze the effects of thyroid hormone on the heart and vascular system and discuss the pathophysiologic mechanisms of heart failure during pregnancy.
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