Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The end can justify the means.

M J Ratcliffe1, E Paramithiotis

  • 1Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.

Seminars in Immunology
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ontogeny and cloning of B cells in the bursa of Fabricius.

Immunology today·2014
Same author

Ontogeny of pre-B cells in the hatched chicken.

Immunology today·2014
Same author

Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-alpha release from human alveolar macrophages.

The European respiratory journal·2007
Same author

Lymphoid signal transduction mechanisms linked to cellular prion protein.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2005
Same author

A positive role for the PP2A catalytic subunit in Wnt signal transduction.

The Journal of biological chemistry·2000
Same author

The chicken B-cell receptor complex and its role in avian B-cell development.

Immunological reviews·2000
Same journal

Myeloid cells as sources and targets of IL-1 family cytokines in cancer.

Seminars in immunology·2026
Same journal

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same journal

Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

Seminars in immunology·2026
Same journal

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.

Seminars in immunology·2026
Same journal

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives.

Seminars in immunology·2026
Same journal

Introduction to the special issue: T<sub>H</sub>9 cells in diseases.

Seminars in immunology·2026
See all related articles

Avian B cell development, particularly in the bursa of Fabricius, generates diverse antibody responses through unique immunoglobulin gene diversification mechanisms, differing significantly from mammals.

Area of Science:

  • Immunology
  • Developmental Biology
  • Genetics

Background:

  • B lymphocyte development is crucial for adaptive immunity.
  • The bursa of Fabricius is central to avian B cell development and antibody diversity.
  • Avian B cell development pathways present unique features compared to mammals.

Purpose of the Study:

  • To review key differences in B cell development between avian and mammalian species.
  • To highlight the specialized mechanisms of immunoglobulin gene diversification in chickens.
  • To provide an overview of avian B cell development.

Main Methods:

  • Comparative analysis of avian and mammalian B cell development pathways.
  • Review of existing literature on immunoglobulin gene diversification in chickens.

Related Experiment Videos

  • Examination of the role of the bursa of Fabricius.

    • Main Results:

    • Avian B cell development involves distinct processes compared to mammalian B cell development.
    • Chickens possess a unique mechanism for diversifying immunoglobulin V region genes.
    • The bursa of Fabricius is essential for generating a pre-immune B cell repertoire in birds.

    Conclusions:

    • Avian and mammalian B cell development exhibit significant differences.
    • The chicken's immunoglobulin gene diversification mechanism is a key distinction.
    • Understanding these differences enhances our knowledge of adaptive immunity.