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Updated: Jun 4, 2026

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages
Published on: October 25, 2017
[Autophagy and pathogens: «Bon appétit Messieurs!»]
Pierre-Emmanuel Joubert1, Isabel Pombo Grégoire, Grégory Meiffren
1Inserm U851, Université de Lyon 1, IFR128, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France.
Abstract:
Autophagy is a highly conserved, self-degradative pathway for clearance and recycling of cytoplasmic contents. This ubiquitous cell intrinsic process can be used as a defence mechanism against intracellular pathogens. Indeed autophagy is increased upon pathogen detection, and experimental extinction in vitro and in vivo of this cellular process has been demonstrated as a crucial role to control intracellular pathogens. Co-evolution between host-cells and pathogens has selected numerous micoorganisms able to avoid or usurp autophagy to their own benefit. Understanding mechanisms underlying the anti-microbial properties of autophagy as well as those used by certain pathogens to escape this cellular process might be crucial to manipulate this cellular function in order to prevent or treat infectious diseases.
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