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Published on: January 16, 2015
Debrisoquine hydroxylation and sulfamethazine acetylation in a Chinese population
Abstract:
Both debrisoquine hydroxylation and sulfamethazine acetylation phenotypes were studied in the same native Chinese population. Debrisoquine hydroxylation status was determined by HPLC assay of debrisoquine metabolic ratio in urine after a single oral dose of 10 mg debrisoquine. Three poor metabolizers were found in 220 subjects (1.36%). One hundred and one subjects of this population previously debrisoquine phenotyped were also tested for acetylation phenotyping on a separate occasion. Their acetylation status were determined by HPLC assay of "% acetylation" after a single oral dose of 1 g sulfamethazine. Twenty (19.8%) slow acetylators were found. There were no significant association between the 2 metabolic pathways.
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