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Updated: Jun 4, 2026
09:04
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Total synthesis of citridone A
Tomoko Miyagawa1, Keisuke Nagai, Asami Yamada
1School of Pharmacy, Kitasato University, Tokyo, Japan.
Organic Letters
|February 11, 2011
Summary
Researchers achieved the first total synthesis of citridone A. Key reactions included regioselective intramolecular iodocyclization and stereoselective palladium-catalyzed coupling.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Citridone A is a natural product with potential biological activity.
- The total synthesis of complex natural products is a significant challenge in organic chemistry.
Purpose of the Study:
- To report the first total synthesis of citridone A.
- To develop efficient and selective synthetic methodologies.
Main Methods:
- Regioselective intramolecular iodocyclization.
- Regio- and stereoselective palladium(0)-catalyzed coupling.
- Multi-step synthesis of complex organic molecules.
Main Results:
- Successful completion of the first total synthesis of citridone A.
- Demonstration of the utility of key synthetic steps for complex molecule construction.
Conclusions:
- The developed synthetic route provides access to citridone A.
- The key reactions employed are valuable tools for organic synthesis.
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