Current Italian practices regarding the management of hyperbilirubinaemia in preterm infants

Carlo Dani1, Chiara Poggi, Jacopo Barp

  • 1Section of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital of Florence, Italy. cdani@unifi.It

Insights

Management of jaundice in preterm infants varies across Italy. National guidelines and a kernicterus registry are needed to standardize care and improve outcomes for hyperbilirubinaemia in these vulnerable infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Public Health

Background:

  • Hyperbilirubinaemia is a common condition in preterm infants.
  • Current management practices for jaundice in preterm infants in Italy lack uniformity.
  • There is a need for standardized national guidelines and a kernicterus registry.

Purpose of the Study:

  • To assess current jaundice management practices in Italian neonatal units.
  • To identify variations in total bilirubin monitoring and treatment protocols.
  • To lay the groundwork for national guidelines and a kernicterus registry.

Main Methods:

  • A questionnaire was distributed to 109 level III neonatal units in Italy.
  • The survey focused on guidelines for bilirubin monitoring and hyperbilirubinaemia treatment in preterm infants.
  • Data on kernicterus occurrence was also collected.

Main Results:

  • A 61% response rate was achieved.
  • 85% of units reported having written guidelines for jaundice management.
  • Significant variability was observed in bilirubin monitoring timing and treatment thresholds.
  • Phototherapy and exchange transfusion rates were reported.
  • Kernicterus cases in both preterm and term infants were documented over 10 years.

Conclusions:

  • Jaundice management in preterm infants is inconsistent across Italy.
  • Shared national guidance is essential for optimizing therapy.
  • Establishing a kernicterus registry is crucial for data collection and guiding future interventions.
Abstract

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