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Updated: Jun 4, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Current Italian practices regarding the management of hyperbilirubinaemia in preterm infants
Carlo Dani1, Chiara Poggi, Jacopo Barp
1Section of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital of Florence, Italy. cdani@unifi.It
Insights
Management of jaundice in preterm infants varies across Italy. National guidelines and a kernicterus registry are needed to standardize care and improve outcomes for hyperbilirubinaemia in these vulnerable infants.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Public Health
Background:
- Hyperbilirubinaemia is a common condition in preterm infants.
- Current management practices for jaundice in preterm infants in Italy lack uniformity.
- There is a need for standardized national guidelines and a kernicterus registry.
Purpose of the Study:
- To assess current jaundice management practices in Italian neonatal units.
- To identify variations in total bilirubin monitoring and treatment protocols.
- To lay the groundwork for national guidelines and a kernicterus registry.
Main Methods:
- A questionnaire was distributed to 109 level III neonatal units in Italy.
- The survey focused on guidelines for bilirubin monitoring and hyperbilirubinaemia treatment in preterm infants.
- Data on kernicterus occurrence was also collected.
Main Results:
- A 61% response rate was achieved.
- 85% of units reported having written guidelines for jaundice management.
- Significant variability was observed in bilirubin monitoring timing and treatment thresholds.
- Phototherapy and exchange transfusion rates were reported.
- Kernicterus cases in both preterm and term infants were documented over 10 years.
Conclusions:
- Jaundice management in preterm infants is inconsistent across Italy.
- Shared national guidance is essential for optimizing therapy.
- Establishing a kernicterus registry is crucial for data collection and guiding future interventions.
Aim:
To assess the current practices existing in Italy for the management of jaundice in preterm infants as preliminary achievement to a call for national guidelines and establishment of a kernicterus registry.
Methods:
A questionnaire (in Supporting Information online) was sent to the 109 level III neonatal units in Italy to ascertain existing guidelines for total bilirubin monitoring and treatment of hyperbilirubinaemia in preterm infants and occurrence of kernicterus.
Results:
There was a 61% (67/109) response rate. Eighty-five per cent of responding units had either written guidelines coming from different literature sources or locally developed. The monitoring of bilirubin varied greatly in timing before, during and after jaundice development. Phototherapy and exchange transfusion were given to 56.0 ± 21.0% and 0.2 ± 0.4% of admitted preterm infants in participating centres. Five cases of kernicterus in preterm infants and eleven cases in term infants were documented over the last 10 years.
Conclusion:
The management of hyperbilirubinaemia in preterm infants is not uniform in Italy and would benefit from shared national guidance together with establishment of a kernicterus registry to guide therapy.
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